مطالعه اثرات پیشگیرانه عصاره چای سبز از ابتلاء به استئاتوز کبد در موش‌های صحرایی تغذیه شده با جیره پر چرب

Background and Objective: Nonalcoholic fatty liver disease is one of the most common causes of chronic liver injury throughout the world. In this study, the preventive effects of green tea extract on fatty liver disease induced by high fat diet is assessed in the rats. Materials and Methods: In this experimental study, male Wistar rats were randomly divided to: Healthy control, Feeding with high fat diet, Feeding with high fat diet plus Clofibrate treatment and Feeding with high fat diet plus Green tea extract treatment groups. The rats treated with either high fat diet for induction of hepatic steatosis and high fat diet plus Clofibrate or Green tea extract for prevention of liver steatosis, at a period of 6 weeks. At the end of experiment, Serum lipid profile, serum biomarkers of liver tissue injury and hepatic antioxidant activity were statistically compared among the groups using one-way ANOVA and Tukey post-tests. The biochemical findings were matched with histopathological verifications. Results: In the rats fed with high-fat diet hypertriglyceridemia and hypercholesterolemia were created. In these animals, increased serum levels of hepatocellular enzymes and significant reduction in antioxidants as well as elevated hepatic lipid peroxidation index were encountered (p=0.001). Extract treatment significantly reduced elevated markers of liver tissue injury (p=0.023) and malondialdehyde (p=0.032), and brought back the liver antioxidants (p=0.028) and the over accumulation of serum lipids towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the preventive effect of green tea extract. Conclusion: Preventive effect of green tea on fatty liver disease in the rats fed with high fat diet is related to its antioxidant properties. Key words: High fat fed diet, Green tea, Antioxidants, Hepatic steatosis   Funding: This research was funded by Tabriz Branch, Islamic Azad University. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Tabriz Branch, Islamic Azad University approved the study.   How to cite this article: Karami Robati A, Ayatollahi Mousavi SA, Hadizadeh S. Study of Nosocomial Fungal infections acquired from Kerman education hospitals. J Rafsanjan Univ Med Sci 2014 13(2): 125-40 [Farsi]